Construction and validation of a novel and severe hepatic injury model in swine focuses on research and training. Observational study

Abstract

Some hepatic wound models have been developed in pigs with the aim of reproducing liver injury; however, the wound shape, severity, and outcome differ among them. The novel injury profile employed in this study differed from that used elsewhere for standardized, repeatable, reproducible, incising-penetrating, vascular, and severe injury in swine. It is made with a cutting object that penetrates deep into the hepatic parenchyma, always affecting the two suprahepatic veins at the point where they merge into the common trunk.The primary outcome was reproducibility and replicability of the surgical method.The secondary outcome was the analysis of some variables (blood loss, survival, and flow) to validate the model. • This novel method of liver injury provides a liver injury with the following characteristics: standardized, incise-penetrated, deep, bloody, and severe. • This model can be used for research (trauma, hepato-bilio-pancreatic, pharmaceutical) and training (damage control surgery). • Method name: Incising-Penetrating, Vascular and Severe Liver Injury Model in Swine.

Keywords

• Incising-Penetrating, Vascular and Severe Liver Injury Model in Swine.