Nature Communications (Sep 2022)
Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation
- Jennifer L. Johnson,
- Elsa Meneses-Salas,
- Mahalakshmi Ramadass,
- Jlenia Monfregola,
- Farhana Rahman,
- Raquel Carvalho Gontijo,
- William B. Kiosses,
- Kersi Pestonjamasp,
- Dale Allen,
- Jinzhong Zhang,
- Douglas G. Osborne,
- Yanfang Peipei Zhu,
- Nathan Wineinger,
- Kasra Askari,
- Danni Chen,
- Juan Yu,
- Scott C. Henderson,
- Catherine C. Hedrick,
- Matilde Valeria Ursini,
- Sergio Grinstein,
- Daniel D. Billadeau,
- Sergio D. Catz
Affiliations
- Jennifer L. Johnson
- Department of Molecular Medicine, The Scripps Research Institute
- Elsa Meneses-Salas
- Department of Molecular Medicine, The Scripps Research Institute
- Mahalakshmi Ramadass
- Department of Molecular Medicine, The Scripps Research Institute
- Jlenia Monfregola
- Department of Molecular Medicine, The Scripps Research Institute
- Farhana Rahman
- Department of Molecular Medicine, The Scripps Research Institute
- Raquel Carvalho Gontijo
- Department of Molecular Medicine, The Scripps Research Institute
- William B. Kiosses
- Division of Inflammation Biology, La Jolla Institute for Immunology
- Kersi Pestonjamasp
- Department of Molecular Medicine, The Scripps Research Institute
- Dale Allen
- Department of Molecular Medicine, The Scripps Research Institute
- Jinzhong Zhang
- Department of Molecular Medicine, The Scripps Research Institute
- Douglas G. Osborne
- The Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic
- Yanfang Peipei Zhu
- Division of Inflammation Biology, La Jolla Institute for Immunology
- Nathan Wineinger
- Research Translational Institute, Statistics, The Scripps Research Institute
- Kasra Askari
- Department of Molecular Medicine, The Scripps Research Institute
- Danni Chen
- Department of Molecular Medicine, The Scripps Research Institute
- Juan Yu
- Department of Molecular Medicine, The Scripps Research Institute
- Scott C. Henderson
- Department of Molecular Medicine, The Scripps Research Institute
- Catherine C. Hedrick
- Division of Inflammation Biology, La Jolla Institute for Immunology
- Matilde Valeria Ursini
- Institute of Genetics and Biophysics A. Buzzati Traverso CNR
- Sergio Grinstein
- Department of Biochemistry, University of Toronto
- Daniel D. Billadeau
- The Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic
- Sergio D. Catz
- Department of Molecular Medicine, The Scripps Research Institute
- DOI
- https://doi.org/10.1038/s41467-022-33230-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 24
Abstract
Responsive exocytosis in neutrophil leukocytes involves actin depolymerisation-dependent sequential release of gelatinase granules, then strongly pro-inflammatory azurophilic granules. Here authors show that the actin nucleator protein WASH facilitates the initial step of innate immune activation by gelatinase granules while inhibiting release of pro-inflammatory granules.
