Longitudinal volumetric assessment of inflammatory arthritis via photoacoustic imaging and Doppler ultrasound imaging

Xiaorui Peng; Zhanpeng Xu; Aaron Dentinger; Shivangi Kewalramani; Janggun Jo; Guan Xu; David Chamberland; Nada Abdulaziz; Girish Gandikota; David Mills; Xueding Wang

Photoacoustics (Jun 2023)

Longitudinal volumetric assessment of inflammatory arthritis via photoacoustic imaging and Doppler ultrasound imaging

Xiaorui Peng,
Zhanpeng Xu,
Aaron Dentinger,
Shivangi Kewalramani,
Janggun Jo,
Guan Xu,
David Chamberland,
Nada Abdulaziz,
Girish Gandikota,
David Mills,
Xueding Wang

Affiliations

Xiaorui Peng: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
Zhanpeng Xu: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
Aaron Dentinger: General Electric Research, Niskayuna, NY, USA
Shivangi Kewalramani: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
Janggun Jo: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
Guan Xu: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA
David Chamberland: Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
Nada Abdulaziz: Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Corresponding authors.
Girish Gandikota: Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Corresponding authors.
David Mills: General Electric Research, Niskayuna, NY, USA; Corresponding authors.
Xueding Wang: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Corresponding author at: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Journal volume & issue: Vol. 31
p. 100514

Abstract

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Aiming at clinical translation, we developed an automatic 3D imaging system combining the emerging photoacoustic imaging with conventional Doppler ultrasound for detecting inflammatory arthritis. This system was built with a GE HealthCare (GEHC) Vivid™ E95 ultrasound system and a Universal Robot UR3 robotic arm. In this work, the performance of this system was examined with a longitudinal study utilizing a clinically relevant adjuvant induced arthritis (AIA) murine model. After adjuvant injection, daily imaging of the rat ankle joints was conducted until joint inflammation was obvious based on visual inspection. Processed imaging results and statistical analyses indicated that both the hyperemia (enhanced blood volume) detected by photoacoustic imaging and the enhanced blood flow detected by Doppler ultrasound reflected the progress of joint inflammation. However, photoacoustic imaging, by leveraging the highly sensitive optical contrast, detected inflammation earlier than Doppler ultrasound, and also showed changes that are more statistically significant. This side-by-side comparison between photoacoustic imaging and Doppler ultrasound using the same commercial grade GEHC ultrasound machine demonstrates the advantage and potential value of the emerging photoacoustic imaging for rheumatology clinical care of arthritis.

Published in Photoacoustics

ISSN: 2213-5979 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Physics: Acoustics. Sound; Science: Physics: Optics. Light
Website: http://www.journals.elsevier.com/photoacoustics/

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