Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles

Agnieszka Czylkowska; Bartłomiej Rogalewicz; Małgorzata Szczesio; Anita Raducka; Katarzyna Gobis; Paweł Szymański; Kamila Czarnecka; Bruno Cury Camargo; Jacek Szczytko; Alexey Babich; Sergey Dubkov; Petr Lazarenko

doi:10.3390/ijms23062980

International Journal of Molecular Sciences (Mar 2022)

Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles

Agnieszka Czylkowska,
Bartłomiej Rogalewicz,
Małgorzata Szczesio,
Anita Raducka,
Katarzyna Gobis,
Paweł Szymański,
Kamila Czarnecka,
Bruno Cury Camargo,
Jacek Szczytko,
Alexey Babich,
Sergey Dubkov,
Petr Lazarenko

Affiliations

Agnieszka Czylkowska: Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland
Bartłomiej Rogalewicz: Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland
Małgorzata Szczesio: Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland
Anita Raducka: Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland
Katarzyna Gobis: Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gen. Hallera 107, 80-416 Gdansk, Poland
Paweł Szymański: Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
Kamila Czarnecka: Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
Bruno Cury Camargo: Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warszawa, Poland
Jacek Szczytko: Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warszawa, Poland
Alexey Babich: Institute of Advanced Materials and Technologies, National Research University of Electronic Technology, Bld. 1, Shokin Square, Zelenograd, 124498 Moscow, Russia
Sergey Dubkov: Institute of Advanced Materials and Technologies, National Research University of Electronic Technology, Bld. 1, Shokin Square, Zelenograd, 124498 Moscow, Russia
Petr Lazarenko: Institute of Advanced Materials and Technologies, National Research University of Electronic Technology, Bld. 1, Shokin Square, Zelenograd, 124498 Moscow, Russia

DOI: https://doi.org/10.3390/ijms23062980
Journal volume & issue: Vol. 23, no. 6
p. 2980

Abstract

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A novel biologically active organic ligand L (N’-benzylidenepyrazine-2-carbohydrazonamide) and its three coordination compounds have been synthesized and structurally described. Their physicochemical and biological properties have been thoroughly studied. Cu(II), Zn(II), and Cd(II) complexes have been analyzed by F-AAS spectrometry and elemental analysis. The way of metal–ligand coordination was discussed based on FTIR spectroscopy and UV-VIS-NIR spectrophotometry. The thermal behavior of investigated compounds was studied in the temperature range 25–800 °C. All compounds are stable at room temperature. The complexes decompose in several stages. Magnetic studies revealed strong antiferromagnetic interaction. Their cytotoxic activity against A549 lung cancer cells have been studied with promising results. We have also investigated the biological effect of coating studied complexes with silver nanoparticles. The morphology of the surface was studied using SEM imaging.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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