Therapeutic Advances in Musculoskeletal Disease (Dec 2019)

Treat-to-target strategy for knee osteoarthritis. International technical expert panel consensus and good clinical practice statements

  • Alberto Migliore,
  • Gianfranco Gigliucci,
  • Liudmila Alekseeva,
  • Sachin Avasthi,
  • Raveendhara R Bannuru,
  • Xavier Chevalier,
  • Thierry Conrozier,
  • Sergio Crimaldi,
  • Nemanja Damjanov,
  • Gustavo Constantino de Campos,
  • Demirhan Diracoglu,
  • Gabriel Herrero-Beaumont,
  • Giovanni Iolascon,
  • Ruxandra Ionescu,
  • Natasa Isailovic,
  • Jörg Jerosch,
  • Jorge Lains,
  • Emmanuel Maheu,
  • Souzi Makri,
  • Natalia Martusevich,
  • Marco Matucci Cerinc,
  • Mihaela Micu,
  • Karel Pavelka,
  • Robert J Petrella,
  • Umberto Tarantino,
  • Raghu Raman

DOI
https://doi.org/10.1177/1759720X19893800
Journal volume & issue
Vol. 11

Abstract

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Background: In this work, we aimed to establish a clinical target in the management of knee osteoarthritis (KOA) and to propose good clinical practice (GCP) statements for carrying out a treat-to-target strategy. Methods: A steering committee of seven experts had formulated a provisional set of recommendations that were exposed for discussion and modification to a technical expert panel (TEP) of 25 multidisciplinary experts from Europe, North America, South America and Asia. The level of evidence and strength of each recommendation was discussed. The TEP formulated overarching principles and GCP statements based on the level of agreement for each item with a vote using a 10-point numerical scale. Results: Two overarching principles and 10 GCP statements were formulated by the TEP. These GCP statements suggest: treatment should achieve clinical improvement bringing the patient to the Patient Acceptable Symptom State (PASS); pharmacological and nonpharmacological treatment should begin as early as possible, with an early diagnosis of symptomatic KOA; the patient should be evaluated every 3–6 months; risk factors of KOA progression should be identified and managed with patients at the beginning of the treatment and monitored regularly; treatment should be adapted according to patient phenotype and disease severity; healthy lifestyle must be promoted and monitored. The level of agreement average ranged from 8.7 to 9.6 on scale. Conclusions: The proposed overarching principles and GCP statements have the aim of involving patients, general practitioners and multidisciplinary specialists in sharing a therapeutic treat-to-target strategy for KOA management based on the best evidence and expert opinions.