Communications Biology (Jun 2022)
GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton
- Christina Wolf,
- Alireza Pouya,
- Sara Bitar,
- Annika Pfeiffer,
- Diones Bueno,
- Liliana Rojas-Charry,
- Sabine Arndt,
- David Gomez-Zepeda,
- Stefan Tenzer,
- Federica Dal Bello,
- Caterina Vianello,
- Sandra Ritz,
- Jonas Schwirz,
- Kristina Dobrindt,
- Michael Peitz,
- Eva-Maria Hanschmann,
- Pauline Mencke,
- Ibrahim Boussaad,
- Marion Silies,
- Oliver Brüstle,
- Marta Giacomello,
- Rejko Krüger,
- Axel Methner
Affiliations
- Christina Wolf
- Institute of Molecular Medicine, University Medical Center Mainz
- Alireza Pouya
- Institute of Molecular Medicine, University Medical Center Mainz
- Sara Bitar
- Institute of Molecular Medicine, University Medical Center Mainz
- Annika Pfeiffer
- Institute of Molecular Medicine, University Medical Center Mainz
- Diones Bueno
- Institute of Molecular Medicine, University Medical Center Mainz
- Liliana Rojas-Charry
- Institute of Molecular Medicine, University Medical Center Mainz
- Sabine Arndt
- Institute for Immunology, University Medical Center Mainz
- David Gomez-Zepeda
- Institute for Immunology, University Medical Center Mainz
- Stefan Tenzer
- Institute for Immunology, University Medical Center Mainz
- Federica Dal Bello
- Institute of Molecular Medicine, University Medical Center Mainz
- Caterina Vianello
- Institute of Molecular Medicine, University Medical Center Mainz
- Sandra Ritz
- Institute of Molecular Biology (IMB) gGmbH
- Jonas Schwirz
- Institute of Molecular Biology (IMB) gGmbH
- Kristina Dobrindt
- Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn
- Michael Peitz
- Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn
- Eva-Maria Hanschmann
- Department of Neurology, Medical Faculty, Heinrich-Heine University
- Pauline Mencke
- Translational Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg
- Ibrahim Boussaad
- Translational Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg
- Marion Silies
- Institute of Development Biology and Neurobiology, Johannes Gutenberg-University Mainz
- Oliver Brüstle
- Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn
- Marta Giacomello
- Department of Biology, University of Padova
- Rejko Krüger
- Translational Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg
- Axel Methner
- Institute of Molecular Medicine, University Medical Center Mainz
- DOI
- https://doi.org/10.1038/s42003-022-03487-6
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 15
Abstract
GDAP1 mutations effect Charcot-Marie-Tooth disease 4A by inhibiting the pyruvate dehydrogenase complex and restricting mitochondrial localization of dynamin-related protein 1 through alterations of the actin cytoskeleton.
