The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease

Qian Wang; Yuanxi Zhang; Minghui Wang; Won-Min Song; Qi Shen; Andrew McKenzie; Insup Choi; Xianxiao Zhou; Ping-Yue Pan; Zhenyu Yue; Bin Zhang

doi:10.1038/s41467-019-13144-y

Nature Communications (Nov 2019)

The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease

Qian Wang,
Yuanxi Zhang,
Minghui Wang,
Won-Min Song,
Qi Shen,
Andrew McKenzie,
Insup Choi,
Xianxiao Zhou,
Ping-Yue Pan,
Zhenyu Yue,
Bin Zhang

Affiliations

Qian Wang: Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Yuanxi Zhang: Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Minghui Wang: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Won-Min Song: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Qi Shen: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Andrew McKenzie: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Insup Choi: Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Xianxiao Zhou: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Ping-Yue Pan: Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Zhenyu Yue: Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Bin Zhang: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-019-13144-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Parkinson’s disease (PD) is characterized by neurodegeneration associated with loss of dopaminergic (DA) neurons and deposition of Lewy bodies. Here, Wang et al. use co-expression network analysis to pinpoint disease pathways and propose reduced expression of STMN2 as a cause of presynaptic function loss in PD.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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