Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate

Jan Kudlacek; Jan Kudlacek; Jan Chvojka; Jan Chvojka; Antonin Posusta; Lubica Kovacova; Seung Bong Hong; Seung Bong Hong; Shennan Weiss; Kamila Volna; Petr Marusic; Jakub Otahal; Premysl Jiruska

doi:10.3389/fneur.2017.00687

Frontiers in Neurology (Dec 2017)

Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate

Jan Kudlacek,
Jan Kudlacek,
Jan Chvojka,
Jan Chvojka,
Antonin Posusta,
Lubica Kovacova,
Seung Bong Hong,
Seung Bong Hong,
Shennan Weiss,
Kamila Volna,
Petr Marusic,
Jakub Otahal,
Premysl Jiruska

Affiliations

Jan Kudlacek: Department of Developmental Epileptology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia
Jan Kudlacek: Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czechia
Jan Chvojka: Department of Developmental Epileptology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia
Jan Chvojka: Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czechia
Antonin Posusta: Department of Developmental Epileptology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia
Lubica Kovacova: Department of Developmental Epileptology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia
Seung Bong Hong: Department of Neurology, Samsung Medical Center, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University School of Medicine, Seoul, South Korea
Seung Bong Hong: Samsung Biomedical Research Institute, Seoul, South Korea
Shennan Weiss: Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States
Kamila Volna: Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia
Petr Marusic: Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia
Jakub Otahal: Department of Developmental Epileptology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia
Premysl Jiruska: Department of Developmental Epileptology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia

DOI: https://doi.org/10.3389/fneur.2017.00687
Journal volume & issue: Vol. 8

Abstract

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Pathological high-frequency oscillations are a novel marker used to improve the delineation of epileptogenic tissue and, hence, the outcome of epilepsy surgery. Their practical clinical utilization is curtailed by the inability to discriminate them from physiological oscillations due to frequency overlap. Although it is well documented that pathological HFOs are suppressed by antiepileptic drugs (AEDs), the effect of AEDs on normal HFOs is not well known. In this experimental study, we have explored whether physiological HFOs (sharp-wave ripples) of hippocampal origin respond to AED treatment. The results show that application of a single dose of levetiracetam or lacosamide does not reduce the rate of sharp-wave ripples. In addition, it seems that these new generation drugs do not negatively affect the cellular and network mechanisms involved in sharp-wave ripple generation, which may provide a plausible explanation for the absence of significant negative effects on cognitive functions of these drugs, particularly on memory.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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