Nature Communications (Jan 2019)

The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome

  • Michal R. Gdula,
  • Tatyana B. Nesterova,
  • Greta Pintacuda,
  • Jonathan Godwin,
  • Ye Zhan,
  • Hakan Ozadam,
  • Michael McClellan,
  • Daniella Moralli,
  • Felix Krueger,
  • Catherine M. Green,
  • Wolf Reik,
  • Skirmantas Kriaucionis,
  • Edith Heard,
  • Job Dekker,
  • Neil Brockdorff

DOI
https://doi.org/10.1038/s41467-018-07907-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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The inactive X chromosome (Xi) has an atypical structure, with global loss of TADs, A/B compartments and formation of mega-domains. Here the authors show that the non-canonical SMC family protein, SmcHD1, important for developmental gene silencing on Xi, antagonises TAD formation and compartmentalization on the Xi in a transcription independent way.