Nature Communications (Sep 2020)

mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

  • Niklas Gremke,
  • Pierfrancesco Polo,
  • Aaron Dort,
  • Jean Schneikert,
  • Sabrina Elmshäuser,
  • Corinna Brehm,
  • Ursula Klingmüller,
  • Anna Schmitt,
  • Hans Christian Reinhardt,
  • Oleg Timofeev,
  • Michael Wanzel,
  • Thorsten Stiewe

DOI
https://doi.org/10.1038/s41467-020-18504-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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mTORC1 is a key mediator of drug resistance and also regulates autophagy. In this study, the authors demonstrate that cancer cells with acquired drug resistance exibit metabolic vulnerabilities mediated by high levels of mTORC1 and the consequent inhibition of autophagy.