Effects of prenatal single and mixed bisphenol exposure on bone mineral density in preschool children: A population-based prospective cohort study

Jun Liang; Lixiang Pang; Chunxiu Yang; Jinghua Long; Qian Liao; Peng Tang; Huishen Huang; Huanni Wei; Qian Chen; Kaiqi Yang; Tao Liu; Fangfang Lv; Shun Liu; Dongping Huang; Xiaoqiang Qiu

Ecotoxicology and Environmental Safety (Nov 2023)

Effects of prenatal single and mixed bisphenol exposure on bone mineral density in preschool children: A population-based prospective cohort study

Jun Liang,
Lixiang Pang,
Chunxiu Yang,
Jinghua Long,
Qian Liao,
Peng Tang,
Huishen Huang,
Huanni Wei,
Qian Chen,
Kaiqi Yang,
Tao Liu,
Fangfang Lv,
Shun Liu,
Dongping Huang,
Xiaoqiang Qiu

Affiliations

Jun Liang: Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China
Lixiang Pang: Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China
Chunxiu Yang: The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, China
Jinghua Long: Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China; The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China
Qian Liao: Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China
Peng Tang: Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China
Huishen Huang: Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China
Huanni Wei: Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou 545006, China
Qian Chen: Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China
Kaiqi Yang: Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China
Tao Liu: Huaihua Center for Disease Control and Prevention, Huaihua, Hunan 418000, China
Fangfang Lv: Department of Child and Adolescent Health & Maternal and Child Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China
Shun Liu: Department of Child and Adolescent Health & Maternal and Child Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China
Dongping Huang: Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China; Correspondence to: School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, Guangxi 530021, China.
Xiaoqiang Qiu: Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China; Correspondence to: School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, Guangxi 530021, China.

Journal volume & issue: Vol. 267
p. 115665

Abstract

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Exposure to bisphenols can affect bone mineral density (BMD) in animals and humans. However, the effects of maternal exposure to bisphenols during pregnancy on bone health in preschool children remain unknown. We aimed to assess the effects of prenatal exposure to single and multiple bisphenols on bone health in preschool children. A total of 230 mother–child pairs were included in this study. Generalized linear regression, restricted cubic spline (RCS), principal component analysis (PCA), and Bayesian kernel machine regression (BKMR) were utilized to assess the relationship between bisphenol levels and bone health in preschool children. Each natural log (Ln) unit increase in tetrabromobisphenol A was related to a 0.007 m/s (95 % CI: –0.015, 0.000) decrease in Ln-transformed speed of sound (SOS) among girls. Decreased BMD Z scores in preschool children were found only in the high bisphenol S exposure group (β = -0.568; 95 % CI: –1.087, –0.050) in boys. The risk of low BMD (BMDL) was significantly higher in the middle-exposure group (OR = 4.695; 95 % CI: 1.143, 24.381) and high-exposure group of BPS (OR = 6.165, 95 % CI: 1.445, 33.789) compared with the low-exposure group in boys. In girls, the risk of BMDL decreased with increasing bisphenol A concentration (OR = 0.413, 95 % CI: 0.215, 0.721). RCS analysis revealed a U-shaped nonlinear correlation between BPB concentration and BMDL in girls (P-overall = 0.011, P-nonlinear = 0.009). In PCA, a U-shaped dose–response relationship was found between PC2 and the risk of BMDL (P-overall = 0.048, P-nonlinear = 0.032), and a significant association was only noted in girls when stratified by sex. The BKMR model revealed a horizontal S-shaped curve relationship between bisphenol mixtures and BMDL in girls. The results indicated that prenatal exposure to single and mixed bisphenols can affect BMD in preschool children, exerting nonmonotonic and child sex-specific effects.

Published in Ecotoxicology and Environmental Safety

ISSN: 0147-6513 (Print); 1090-2414 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Technology: Environmental technology. Sanitary engineering: Environmental pollution; Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/ecotoxicology-and-environmental-safety

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