Association between Insulin Resistance and Lipid profile in a Sample of Iraqi Polycystic ovary syndrome Patients

Abstract

A common metabolic disorder in women with polycystic ovarian syndrome (PCOS) is dyslipidemia. Since insulin resistance is a major pathophysiology of PCOS, dyslipidemia in PCOS-affected women may be consistent with that of insulin resistance. This study was planned to determine insulin level in PCOS patients, and interpretation of Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) with lipid profile level. Fifty eight patients and thirty controls were involved for this study. All subjects' lipid profiles, FBS, and insulin levels were examined. Patients with PCOS had significantly higher serum insulin levels than the healthy control group (p 0.05). Insulin resistance in PCOS is significantly higher than in healthy controls. In PCOS patients, there is a negative connection between HOMA-IR and HDL-C. HOMA-IR was found to positively correlate with TG and TC in the patient group where the person coefficient values for (TG,TC and HDL-C) : 0.4486, 0.405 and 0.3109 respectively . Conclusion: dyslipidemia and insulin resistance both lead to the development of atherosclerosis in PCOS patients

Keywords

• Serum insulin, HOMA-IR, lipids profile, polycystic ovarian syndrome