Timing and Efficacy Evaluation of 755-nm Long Pulse Alexandrite Laser and 2% Carteolol Hydrochloride Eye Drops Co-Treatment for Thicker Superficial Infantile Hemangioma

Abstract

WeiKang Shi,1 Lu Jin,2 AiHua Xu,2 Yu Gao,3 Na Zhang4 1Department of Dermatology, Jinhua Maternal and Child Health Care Hospital, Jinhua, Zhejiang Province, People’s Republic of China; 2Department of Nursing, Jinhua Central Hospital, Jinhua, Zhejiang Province, People’s Republic of China; 3Department of Dermatology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People’s Republic of China; 4Department of Dermatology, Jinhua Central Hospital, Jinhua, Zhejiang Province, People’s Republic of ChinaCorrespondence: Na Zhang; Yu Gao, Email [email protected]; [email protected]: Superficial Infantile hemangioma (SIH) is the most common type of IH. Some studies have shown the efficacy of 755-nm long pulse alexandrite laser (LPAL) and topical 2% carteolol hydrochloride (C-HCL) eye drops for the treatment of SIH. This article retrospectively analyzes the safety and efficacy of 755-nm LPAL combined with 2% C-HCL eye drops for treating thicker SIH, and explores the optimal treatment time for SIH.Materials and Methods: This study included 2– 5 mm thick SIH patients who received co-treatment of 755-nm LPAL and 2% C-HCL eye drops. The SIH patients were divided into 3 groups based on their age and IH growth curve: ≤ 1 month (≤ 1M), 1– 3 months (excluding 1 month; 1– 3M), and 3– 12 months (excluding 3 months; 3− 12M).Results: There was no difference in efficacy between the ≤ 1M and the 1– 3M group, and were both better than the 3– 12M group. Furthermore, there was no difference in the average number of treatments between the ≤ 1M and 1– 3M groups and were both less than the 3– 12M group. There was no significant difference in the incidence of adverse reactions between the groups. Compared with the ≤ 1M and 1– 3M groups, the 3– 12M group indicated more permanent skin lesions after the treatment.Conclusion: It was revealed that co-treatment with 755-nm LPAL and 2% C-HCL eye drops is safe and effective against thicker SIH. Compared with the 3– 12M group, ≤ 3 months can achieve better efficacy, requires a shorter treatment time, less likely to leave permanent skin lesions such as scars. Moreover, patients with no proliferation can be observed to 1 month.Keywords: infantile hemangioma, 755-nm long pulse alexandrite laser, 2% carteolol hydrochloride eye drops, treatment timing, efficacy

Keywords

• infantile hemangioma
• 755-nm long pulse alexandrite laser
• 2% carteolol hydrochloride eye drops
• treatment timing
• efficacy