Nature Communications (Jun 2021)

A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects

  • Hélène Choquet,
  • Ronald B. Melles,
  • Deepti Anand,
  • Jie Yin,
  • Gabriel Cuellar-Partida,
  • Wei Wang,
  • 23andMe Research Team,
  • Thomas J. Hoffmann,
  • K. Saidas Nair,
  • Pirro G. Hysi,
  • Salil A. Lachke,
  • Eric Jorgenson

DOI
https://doi.org/10.1038/s41467-021-23873-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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The genetic basis of cataract is not well understood. Here, the authors perform a genome-wide association multiethnic meta-analysis of cataract, finding 37 new loci and replicating known and new loci. They additionally perform sex-specific analyses, identifying new associations specific to women.