PREDIKTORY SIGNIFICANCE OF DNA DAMAGE TO MONONUCLEAR BLOOD CELLS IN EARLY DIAGNOSTICS OF INFECTED PACREATIC NECROSIS

Abstract

OBJECIVE. The evaluation of predictive significance of DNA damage of mononuclear blood cells in patients with pancreatic necrosis. MATERIAL AND METHODS. The work is based on the analyzing the results of the complex treatment of 497 patients with pancreatic necrosis, and in whom DNA damage of mononuclear blood cells was studied by the method of the gel-electrophoresis («DNA-comet» method). RESULTS. In the course of the research, it was possible to introduce and effectively use the «DNA-comet» method in the early diagnostics of pancreatogenic infection. CONCLUSION. The introduction of the method allowed reducing the number of unreasonable surgical interventions in the sterile phase of pancreatic necrosis into 1.9 times, and along with complex therapeutic measures, to reduce the level of overall mortality from 11.1 to 3.9 %.

Keywords

• pancreatic necrosis
• mononuclear blood cells
• the method of «dna-comet»