Frontiers in Immunology (Mar 2024)

Mechanism study of ubiquitination in T cell development and autoimmune disease

  • Hui Yu,
  • Wenyong Yang,
  • Min Cao,
  • Qingqiang Lei,
  • Renbin Yuan,
  • He Xu,
  • Yuqian Cui,
  • Xuerui Chen,
  • Xu Su,
  • Xu Su,
  • Hui Zhuo,
  • Liangbin Lin

DOI
https://doi.org/10.3389/fimmu.2024.1359933
Journal volume & issue
Vol. 15

Abstract

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T cells play critical role in multiple immune processes including antigen response, tumor immunity, inflammation, self-tolerance maintenance and autoimmune diseases et. Fetal liver or bone marrow-derived thymus-seeding progenitors (TSPs) settle in thymus and undergo T cell-lineage commitment, proliferation, T cell receptor (TCR) rearrangement, and thymic selections driven by microenvironment composed of thymic epithelial cells (TEC), dendritic cells (DC), macrophage and B cells, thus generating T cells with diverse TCR repertoire immunocompetent but not self-reactive. Additionally, some self-reactive thymocytes give rise to Treg with the help of TEC and DC, serving for immune tolerance. The sequential proliferation, cell fate decision, and selection during T cell development and self-tolerance establishment are tightly regulated to ensure the proper immune response without autoimmune reaction. There are remarkable progresses in understanding of the regulatory mechanisms regarding ubiquitination in T cell development and the establishment of self-tolerance in the past few years, which holds great potential for further therapeutic interventions in immune-related diseases.

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