Communications Biology (Nov 2021)

Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

  • Luan Nguyen,
  • Myrthe Jager,
  • Ruby Lieshout,
  • Petra E. de Ruiter,
  • Mauro D. Locati,
  • Nicolle Besselink,
  • Bastiaan van der Roest,
  • Roel Janssen,
  • Sander Boymans,
  • Jeroen de Jonge,
  • Jan N. M. IJzermans,
  • Michail Doukas,
  • Monique M. A. Verstegen,
  • Ruben van Boxtel,
  • Luc J. W. van der Laan,
  • Edwin Cuppen,
  • Ewart Kuijk

DOI
https://doi.org/10.1038/s42003-021-02839-y
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 9

Abstract

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Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer. The authors report that, compared to healthy liver, these precancerous liver diseases do not result in a detectable increase of mutations, nor an alteration of mutation types in individual liver stem cells.