Research progress of interleukin-15 in cancer immunotherapy

Menghan Cai; Xuan Huang; Xuan Huang; Xiting Huang; Xiting Huang; Dianwen Ju; Dianwen Ju; Yi Zhun Zhu; Li Ye; Li Ye; Li Ye

doi:10.3389/fphar.2023.1184703

Frontiers in Pharmacology (May 2023)

Research progress of interleukin-15 in cancer immunotherapy

Menghan Cai,
Xuan Huang,
Xuan Huang,
Xiting Huang,
Xiting Huang,
Dianwen Ju,
Dianwen Ju,
Yi Zhun Zhu,
Li Ye,
Li Ye,
Li Ye

Affiliations

Menghan Cai: School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, Macau SAR, China
Xuan Huang: Minhang Hospital and Department of Biological Medicines at School of Pharmacy, Fudan University, Shanghai, China
Xuan Huang: Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, China
Xiting Huang: Minhang Hospital and Department of Biological Medicines at School of Pharmacy, Fudan University, Shanghai, China
Xiting Huang: Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, China
Dianwen Ju: Minhang Hospital and Department of Biological Medicines at School of Pharmacy, Fudan University, Shanghai, China
Dianwen Ju: Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, China
Yi Zhun Zhu: School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, Macau SAR, China
Li Ye: School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, Macau SAR, China
Li Ye: Minhang Hospital and Department of Biological Medicines at School of Pharmacy, Fudan University, Shanghai, China
Li Ye: Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, China

DOI: https://doi.org/10.3389/fphar.2023.1184703
Journal volume & issue: Vol. 14

Abstract

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Interleukin-15 (IL-15) is a cytokine that belongs to the interleukin-2 (IL-2) family and is essential for the development, proliferation, and activation of immune cells, including natural killer (NK) cells, T cells and B cells. Recent studies have revealed that interleukin-15 also plays a critical role in cancer immunotherapy. Interleukin-15 agonist molecules have shown that interleukin-15 agonists are effective in inhibiting tumor growth and preventing metastasis, and some are undergoing clinical trials. In this review, we will summarize the recent progress in interleukin-15 research over the past 5 years, highlighting its potential applications in cancer immunotherapy and the progress of interleukin-15 agonist development.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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