Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death

Abstract

The transcription termination factor Rho is essential for growth in some bacteria but not in others. Here, Botellaet al. show that Rho inactivation causes extensive pervasive transcription and loss of viability of the pathogen Mycobacterium tuberculosis both in vitroand in a mouse model of infection.