Frontiers in Bioengineering and Biotechnology (Jul 2022)
Prediction of protein secondary structure based on an improved channel attention and multiscale convolution module
Abstract
Prediction of the protein secondary structure is a key issue in protein science. Protein secondary structure prediction (PSSP) aims to construct a function that can map the amino acid sequence into the secondary structure so that the protein secondary structure can be obtained according to the amino acid sequence. Driven by deep learning, the prediction accuracy of the protein secondary structure has been greatly improved in recent years. To explore a new technique of PSSP, this study introduces the concept of an adversarial game into the prediction of the secondary structure, and a conditional generative adversarial network (GAN)-based prediction model is proposed. We introduce a new multiscale convolution module and an improved channel attention (ICA) module into the generator to generate the secondary structure, and then a discriminator is designed to conflict with the generator to learn the complicated features of proteins. Then, we propose a PSSP method based on the proposed multiscale convolution module and ICA module. The experimental results indicate that the conditional GAN-based protein secondary structure prediction (CGAN-PSSP) model is workable and worthy of further study because of the strong feature-learning ability of adversarial learning.
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