Nature Communications (Jul 2017)

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

  • Manav Korpal,
  • Xiaoling Puyang,
  • Zhenhua Jeremy Wu,
  • Roland Seiler,
  • Craig Furman,
  • Htoo Zarni Oo,
  • Michael Seiler,
  • Sean Irwin,
  • Vanitha Subramanian,
  • Jaya Julie Joshi,
  • Chris K. Wang,
  • Victoria Rimkunas,
  • Davide Tortora,
  • Hua Yang,
  • Namita Kumar,
  • Galina Kuznetsov,
  • Mark Matijevic,
  • Jesse Chow,
  • Pavan Kumar,
  • Jian Zou,
  • Jacob Feala,
  • Laura Corson,
  • Ryan Henry,
  • Anand Selvaraj,
  • Allison Davis,
  • Kristjan Bloudoff,
  • James Douglas,
  • Bernhard Kiss,
  • Morgan Roberts,
  • Ladan Fazli,
  • Peter C. Black,
  • Peter Fekkes,
  • Peter G. Smith,
  • Markus Warmuth,
  • Lihua Yu,
  • Ming-Hong Hao,
  • Nicholas Larsen,
  • Mads Daugaard,
  • Ping Zhu

DOI
https://doi.org/10.1038/s41467-017-00147-w
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

Muscle-invasive bladder cancer (MIBC) is a potentially lethal disease. Here the authors characterize diverse genetic alterations in MIBC that convergently lead to constitutive activation of PPARgamma/RXRalpha and result in immunosurveillance escape by inhibiting CD8+ T-cell recruitment.