Nature Communications (Jan 2020)

Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity

  • Mariya B. Shapiro,
  • Tracy Cheever,
  • Delphine C. Malherbe,
  • Shilpi Pandey,
  • Jason Reed,
  • Eun Sung Yang,
  • Keyun Wang,
  • Amarendra Pegu,
  • Xuejun Chen,
  • Don Siess,
  • David Burke,
  • Heidi Henderson,
  • Rebecca Lewinsohn,
  • Miranda Fischer,
  • Jeffrey J. Stanton,
  • Michael K. Axthelm,
  • Christoph Kahl,
  • Byung Park,
  • Anne D. Lewis,
  • Jonah B. Sacha,
  • John R. Mascola,
  • Ann J. Hessell,
  • Nancy L. Haigwood

DOI
https://doi.org/10.1038/s41467-019-13972-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Broadly neutralizing antibodies (bNAbs) are being evaluated for HIV post-exposure prophylaxis (PEP) in the setting of vertical transmission. Here, using a macaque model of perinatal SHIV infection, the authors show that PEP for infant macaques within 30–48 h of SHIV exposure is highly effective using either bNAbs or ART.