Dataset on the prognostic value of cardiac biomarkers used in clinical routine in patients with severe aortic stenosis undergoing valve replacement
Fabian Barbieri,
Thomas Senoner,
Agne Adukauskaite,
Stephan Dobner,
Johannes Holfeld,
Severin Semsroth,
Thomas Lambert,
David Zweiker,
Thomas Theurl,
Peter Rainer,
Albrecht Schmidt,
Gudrun Feuchtner,
Clemens Steinwender,
Uta Hoppe,
Florian Hintringer,
Axel Bauer,
Silvana Müller,
Michael Grimm,
Bernhard Pfeifer,
Wolfgang Dichtl
Affiliations
Fabian Barbieri
University Clinic of Internal Medicine III, Medical University Innsbruck, Innsbruck, Austria; Corresponding author.
Thomas Senoner
University Clinic of Internal Medicine III, Medical University Innsbruck, Innsbruck, Austria
Agne Adukauskaite
University Clinic of Internal Medicine III, Medical University Innsbruck, Innsbruck, Austria
Stephan Dobner
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland
Johannes Holfeld
University Clinic of Heart Surgery, Medical University Innsbruck, Innsbruck, Austria
Severin Semsroth
University Clinic of Heart Surgery, Medical University Innsbruck, Innsbruck, Austria
Thomas Lambert
Department of Cardiology, Kepler University Hospital, Medical Faculty, Johannes Kepler University Linz, Austria
David Zweiker
Department of Internal Medicine, Division of Cardiology, Medical University Graz, Graz, Austria
Thomas Theurl
University Clinic of Internal Medicine II, Paracelsus Medical University, Salzburg, Austria
Peter Rainer
Department of Internal Medicine, Division of Cardiology, Medical University Graz, Graz, Austria
Albrecht Schmidt
Department of Internal Medicine, Division of Cardiology, Medical University Graz, Graz, Austria
Gudrun Feuchtner
University Clinic of Radiology, Medical University Innsbruck, Innsbruck, Austria
Clemens Steinwender
Department of Cardiology, Kepler University Hospital, Medical Faculty, Johannes Kepler University Linz, Austria
Uta Hoppe
University Clinic of Internal Medicine II, Paracelsus Medical University, Salzburg, Austria
Florian Hintringer
University Clinic of Internal Medicine III, Medical University Innsbruck, Innsbruck, Austria
Axel Bauer
University Clinic of Internal Medicine III, Medical University Innsbruck, Innsbruck, Austria
Silvana Müller
University Clinic of Internal Medicine III, Medical University Innsbruck, Innsbruck, Austria
Michael Grimm
University Clinic of Heart Surgery, Medical University Innsbruck, Innsbruck, Austria
Bernhard Pfeifer
Institute of Clinical Epidemiology, Tirol Kliniken, Innsbruck, Austria; Institute of Electrical and Biomedical Engineering, University for Health Sciences, Medical Informatics and Technology (UMIT), Hall in Tirol, Austria
Wolfgang Dichtl
University Clinic of Internal Medicine III, Medical University Innsbruck, Innsbruck, Austria
Hereby, the supplemental data of the research article “Long-Term Prognostic Value of High-Sensitivity Troponin T added to N-Terminal Pro Brain Natriuretic Peptide Plasma Levels before Valve Replacement for Severe Aortic Stenosis” are presented [1]. It offers enhanced input on the predictive value of these biomarkers considering the influence of the presence of concomitant coronary artery disease (CAD) in various severities as well as an additional cox proportional hazard model on cardiovascular mortality. Furthermore, the receiver operating characteristic (ROC) curves are shown as figures. The material described increases therefore the understanding of the predictive value of these already routinely available biomarkers and reduces the risk of potential bias due to possible confounding factors. It also underlines the urge for a multi-factorial approach in diagnostics to detect the optimal point for referral to valve replacement other than just symptomatic status, an observed reduction in left ventricular ejection fraction or the presence of CAD with the necessity for coronary artery bypass grafting (CABG) [2]. The data of the 3595 patients were gathered retrospectively at a consortium of four university hospital centers in Austria and combined with prospectively collected data on cardiovascular and all-cause mortality. Keywords: High sensitivity troponin T, N-terminal pro brain natiuretic peptide, Severe aortic stenosis, Valve replacement, Survival, Risk stratification