Antibacterial Activity of Dental Composite with Ciprofloxacin Loaded Silver Nanoparticles
Wafa Arif,
Nosheen Fatima Rana,
Iqra Saleem,
Tahreem Tanweer,
Muhammad Jawad Khan,
Sohad Abdulkaleg Alshareef,
Huda M. Sheikh,
Fatima S. Alaryani,
Manal Othman AL-Kattan,
Hanan Ali Alatawi,
Farid Menaa,
Aroosa Younis Nadeem
Affiliations
Wafa Arif
Department of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, Pakistan
Nosheen Fatima Rana
Department of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, Pakistan
Iqra Saleem
Department of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, Pakistan
Tahreem Tanweer
Department of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, Pakistan
Muhammad Jawad Khan
Department of Robotics & Artificial Intelligence, School of Mechanical & Manufacturing Engineering, National University of Science & Technology, Islamabad 44000, Pakistan
Sohad Abdulkaleg Alshareef
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia
Huda M. Sheikh
Department of Biology, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia
Fatima S. Alaryani
Department of Biology, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia
Manal Othman AL-Kattan
Department of Biology, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia
Hanan Ali Alatawi
Department of Biological Sciences, University College of Haqel, University of Tabuk, Tabuk 71491, Saudi Arabia
Farid Menaa
Internal Medicine and Nanomedicine, California Innovations Corporation, San Diego, CA 92037, USA
Aroosa Younis Nadeem
Department of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, Pakistan
Resin composites have been widely used in dental restoration. However, polymerization shrinkage and resultant bacterial microleakage are major limitations that may lead to secondary caries. To overcome this, a new type of antibacterial resin composite containing ciprofloxacin-loaded silver nanoparticles (CIP-AgNPs) were synthesized. The chemical reduction approach successfully produced CIP-AgNPs, as demonstrated by FTIR, zeta potential, scanning electron microscopy, and ultraviolet-visible (UV-vis) spectroscopy. CIP-AgNPs were added to resin composites and the antibacterial activity of the dental composite discs were realized against Enterococcus faecalis, Streptococcus mutans, and the Saliva microcosm. The biocompatibility of modified resin composites was assessed and mechanical testing of modified dental composites was also performed. The results indicated that the antibacterial activity and compressive strength of resin composites containing CIP-AgNPs were enhanced compared to the control group. They were also biocompatible when compared to resin composites containing AgNPs. In short, these results established strong ground application for CIP-AgNP-modified dental composite resins.
