DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER

Abstract

Abstract. Several endogenic and synthetic peptides were investigated in order to reveal their antibacterial activity. The study of dose-depended effects of antibacterial activity of the immunotropic peptide ZP-2, which is included in GM-CSF active center, shown significant antibacterial activity of ZP-2 by action range and by rate of bactericidal activity in case of low concentration. Combined application of substance derived from supernatant of CD34+CD45-cells and synthetic peptide ZP-2 enhances significantly actions of each other. Probably, this effect is connected with various mechanisms of their influence on bacteria. The obtained facts indicate that synthetic peptide has not only immunostimulating action but it also promotes a direct antibacterial activity. These data support an idea that synthetic peptides have good perspectives in case of development new antibacterial drugs with unique characteristics.

Keywords

• gm-csf
• peptides
• defensins