Nature Communications (Jun 2021)

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified

  • Koen Debackere,
  • Lukas Marcelis,
  • Sofie Demeyer,
  • Marlies Vanden Bempt,
  • Nicole Mentens,
  • Olga Gielen,
  • Kris Jacobs,
  • Michael Broux,
  • Gregor Verhoef,
  • Lucienne Michaux,
  • Carlos Graux,
  • Iwona Wlodarska,
  • Philippe Gaulard,
  • Laurence de Leval,
  • Thomas Tousseyn,
  • Jan Cools,
  • Daan Dierickx

DOI
https://doi.org/10.1038/s41467-021-24037-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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Peripheral T cell lymphoma (PTCL) not otherwise specified (NOS) is a subgroup of PTCL, which has no distinctive features and is poorly characterized at the genetic level. Here, the authors identify two fusion transcripts that activate T cell receptor complex signalling and confer therapeutic vulnerability in PTCL-NOS.