Nature Communications (Nov 2019)
Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases
Abstract
Pif1 plays multiple roles in maintaining genome stability and preferentially unwinds forked dsDNA. Here the authors solve the structure of Bacteroides sp Pif1 (BaPif1) in complex with a symmetrical double forked dsDNA and provide unprecedented insights into forked dsDNA unwinding by BaPif1.