Nature Communications (Nov 2019)

Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases

  • Nannan Su,
  • Alicia K. Byrd,
  • Sakshibeedu R. Bharath,
  • Olivia Yang,
  • Yu Jia,
  • Xuhua Tang,
  • Taekjip Ha,
  • Kevin D. Raney,
  • Haiwei Song

DOI
https://doi.org/10.1038/s41467-019-13414-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Pif1 plays multiple roles in maintaining genome stability and preferentially unwinds forked dsDNA. Here the authors solve the structure of Bacteroides sp Pif1 (BaPif1) in complex with a symmetrical double forked dsDNA and provide unprecedented insights into forked dsDNA unwinding by BaPif1.