Design, Synthesis and Antiviral Potential of 14-Aryl/Heteroaryl-14<em>H</em>-dibenzo<em>[a,j]</em>xanthenes Using an Efficient Polymer-Supported Catalyst

Abstract

Polyethyleneglycol bound sulfonic acid (PEG-OSO₃H), a chlorosulphonic acid-modified polyethylene glycol was successfully used as an efficient and eco-friendly polymeric catalyst in the synthesis of 14-aryl/heteroaryl-14<em>H</em>-dibenzo[<em>a,j</em>]xanthenes obtained from the reaction of 2-naphthol and carbonyl compounds under solvent-free conditions with short reaction times and excellent yields. The biological properties of these synthesized title compounds revealed that compounds <strong>3b</strong>, <strong>3c</strong>, <strong>3f</strong> and <strong>3i</strong> showed highly significant anti-viral activity against tobacco mosaic virus.

Keywords

• aryl aldehydes
• 2-naphthol
• PEG-OSO&lt;sub&gt;3&lt;/sub&gt;H
• neat reaction
• xanthenes
• tobacco mosaic virus