Emergence and evolution of TP53 mutations are key features of disease progression in myelodysplastic patients with lower-risk del(5q) treated with lenalidomide

• Laurence Lodé,
• Audrey Ménard,
• Laurent Flet,
• Steven Richebourg,
• Marion Loirat,
• Marion Eveillard,
• Yannick Le Bris,
• Catherine Godon,
• Olivier Theisen,
• Anne-Laure Gagez,
• Guillaume Cartron,
• Thérèse Commes-Maerten,
• Bruno Villemagne,
• Odile Luycx,
• Pascal Godmer,
• Catherine Pellat-Deceunynck,
• Thierry Soussi,
• Marie C. Béné,
• Jacques Delaunay,
• Pierre Peterlin

Affiliations

Laurence Lodé

Hematology Biology, Montpellier University Hospital, France;Hematology Biology, Nantes University Hospital, France;UMR CNRS5235, University of Montpellier;Bio2M team, Institut de Recherche en Medecine Regeneratrice, INSERM U1183, Hôpital Saint-Eloi, Montpellier, France

Audrey Ménard

Hematology Biology, Nantes University Hospital, France

Laurent Flet

Pharmacy Unit, Nantes University Hospital, France

Steven Richebourg

Cytogenetics, Québec University Hospital, Hôpital Saint Sacrement, Québec, Canada

Marion Loirat

Hematology Clinic, Nantes University Hospital, France

Marion Eveillard

Hematology Biology, Nantes University Hospital, France

Yannick Le Bris

Hematology Biology, Nantes University Hospital, France

Catherine Godon

Hematology Biology, Nantes University Hospital, France

Olivier Theisen

Hematology Biology, Nantes University Hospital, France

Anne-Laure Gagez

Hematology Department, University Hospital, Montpellier, France

Guillaume Cartron

UMR CNRS5235, University of Montpellier;Hematology Department, University Hospital, Montpellier, France

Thérèse Commes-Maerten

Bio2M team, Institut de Recherche en Medecine Regeneratrice, INSERM U1183, Hôpital Saint-Eloi, Montpellier, France

Bruno Villemagne

Hematology Clinic, CH La Roche-sur-Yon, France

Odile Luycx

Hematology Clinic, CH Lorient, France

Pascal Godmer

Hematology Clinic, CH Vannes, France

Catherine Pellat-Deceunynck

CRCINA, INSERM, CNRS, Angers University, Nantes University, France

Thierry Soussi

Sorbonne Université, UPMC Univ Paris 06, France; INSERM, U1138, Centre de Recherche des Cordeliers, Paris, France; Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Stockholm, Sweden

Marie C. Béné

Hematology Biology, Nantes University Hospital, France

Jacques Delaunay

Hematology Clinic, Nantes University Hospital, France;Hematology Department, Le Confluent, Nantes, France

Pierre Peterlin

Hematology Clinic, Nantes University Hospital, France