Фармакокинетика и Фармакодинамика (Apr 2013)

HPLC determination, pharmacokinetics and relative bioavailability of levofloxacin produced by «OZONE», Russia

  • S. N. Kondratenko,
  • A. K. Starodubtcev,
  • E. A. Senik,
  • O. V. Dralova,
  • S. N. Kudinova

Journal volume & issue
Vol. 0, no. 1
pp. 23 – 26

Abstract

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A simple, specific, sensitive and reproducible good method for quantitative determination of Levofloxacin in plasma using HPLC with UV-spectrophotometric detection. With this technique the pharmacokinetics and relative bioavailability of domestic generic of levofloxacin in 18 healthy volunteers after a single oral dose of 500 mg. Found that the drug being tested, levofloxacin (OOO «Ozone», Russia) is bioequivalent to the reference drugs Tavanic® («Sanofi Winthrop Industry», France).

Keywords