Molecular & Cellular Oncology (Nov 2021)
SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy
Abstract
The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.
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