Identification of TMB, CD8 T‐cell abundance, and homologous repair pathway mutation frequency as predictors of the benefit–toxicity ratio of anti‐PD‐1/PD‐L1 therapy

• Junyu Long,
• Xu Yang,
• Jin Bian,
• Dongxu Wang,
• Anqiang Wang,
• Yu Lin,
• Mingjun Zheng,
• Haohai Zhang,
• Xinting Sang,
• Haitao Zhao

Affiliations

Junyu Long

Department of Liver Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC) Beijing China

Xu Yang

Department of Liver Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC) Beijing China

Jin Bian

Department of Liver Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC) Beijing China

Dongxu Wang

Department of Liver Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC) Beijing China

Anqiang Wang

Department of Gastrointestinal Surgery Key Laboratory of Carcinogenesis and Translational Research Ministry of Education Peking University Cancer Hospital and Institute Beijing China

Yu Lin

Shenzhen Withsum Technology Limited Shenzhen China

Mingjun Zheng

Department of Obstetrics and Gynecology University Hospital, LMU Munich Munich Germany

Haohai Zhang

Liver Center and The Transplant Institute Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts USA

Xinting Sang

Department of Liver Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC) Beijing China

Haitao Zhao

Department of Liver Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC) Beijing China