Oral administration of Arctium tomentosum Mill. CO2-extract alleviates the diet induced metabolic disorder in mice

Abstract

Nowadays, the metabolic disorder exists along with other pathological conditions, such as hyperglycemia, hypertriglyceridemia, hypercholesterolemia and gain of the excess abdominal fat. It has negative impact on human health, but especially the liver health. The present work was designed to study the liver supporting effect of ATE on mice with high-fructose and high-sucrose diet induced metabolic disorder. The study was conducted on mice, divided into following groups: NC; untreated MD; group with MD treated by ATE at the doses 50, 200 and 400 mg/kg respectively. As a result, the liver supporting effect of ATE at the doses of 200 and 400 mg/kg was shown in the values of body weight, relative weight of the liver, kidneys and epidydimal fat. The same was observed in plasma biochemistry, in which groups treated with ATE showed normal levels of triglycerides, total and low-density cholesterol, ALT, AST. The treatment by 400 mg/kg ATE significantly inhibited the lipid accumulation and hepatocytes degeneration in the liver histological structure. In conclusion these findings provide the potential therapeutic usefulness into the effects of ATE in the treatment of metabolic disorder. Furthermore, it suggests that ATE has hepatoprotective effect which is conducted via its antioxidant properties.