Frontiers in Immunology (Jul 2012)

Myeloid-Derived Suppressor Cells: Mechanisms of Action and recent advances in their role in transplant tolerance

  • Nahzli eDilek,
  • Nahzli eDilek,
  • Romain eVuillefroy de Silly,
  • Gilles eBlancho,
  • Gilles eBlancho,
  • Bernard eVanhove,
  • Bernard eVanhove

DOI
https://doi.org/10.3389/fimmu.2012.00208
Journal volume & issue
Vol. 3

Abstract

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Myeloid derived suppressor cells (MDSC) are a heterogeneous population of immature hematopoietic precursors known to suppress immune responses in infection, chronic inflammation, cancer and autoimmunity. In this paper we review recent findings detailing their mode of action and discuss recent reports that suggest that MDSC are also expanded during transplantation and that modulation of MDSC can participate in preventing graft rejection.

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