PLoS ONE (Jan 2019)

Hypoalbuminemia is a frequent marker of increased mortality in cardiogenic shock.

  • Toni Jäntti,
  • Tuukka Tarvasmäki,
  • Veli-Pekka Harjola,
  • John Parissis,
  • Kari Pulkki,
  • Tuija Javanainen,
  • Heli Tolppanen,
  • Raija Jurkko,
  • Mari Hongisto,
  • Anu Kataja,
  • Alessandro Sionis,
  • Jose Silva-Cardoso,
  • Marek Banaszewski,
  • Jindrich Spinar,
  • Alexandre Mebazaa,
  • Johan Lassus,
  • CardShock investigators

DOI
https://doi.org/10.1371/journal.pone.0217006
Journal volume & issue
Vol. 14, no. 5
p. e0217006

Abstract

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IntroductionThe prevalence of hypoalbuminemia, early changes of plasma albumin (P-Alb) levels, and their effects on mortality in cardiogenic shock are unknown.Materials and methodsP-Alb was measured from serial blood samples in 178 patients from a prospective multinational study on cardiogenic shock. The association of hypoalbuminemia with clinical characteristics and course of hospital stay including treatment and procedures was assessed. The primary outcome was all-cause 90-day mortality.ResultsHypoalbuminemia (P-Alb ConclusionsHypoalbuminemia was a frequent finding early in cardiogenic shock, and P-Alb levels decreased during hospital stay. Low P-Alb at baseline was associated with mortality independently of other previously described risk factors. Thus, plasma albumin measurement should be part of the initial evaluation in patients with cardiogenic shock.Trial registrationNCT01374867 at ClinicalTrials.gov.