Mechanisms of cell death in neurodegenerative processes

Abstract

Processes of apoptotic cell death as the main mechanism of neurodegeneration in different types of pathologies are described. Evidence is presented on cell cycle activation in differentiated neurons and on relation between proliferation factors and regulation of neuron death. Hypothesis is referred on possible therapeutic strategies of the mechanisms of pathogenesis of degenerative diseases of nervous system.

Keywords

• neurodegenerative diseases
• apoptosis
• cell cycle
• apoptosis inhibitors