Nature Communications (Sep 2022)
Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma
- Alexandra Gyurdieva,
- Stefan Zajic,
- Ya-Fang Chang,
- E. Andres Houseman,
- Shan Zhong,
- Jaegil Kim,
- Michael Nathenson,
- Thomas Faitg,
- Mary Woessner,
- David C. Turner,
- Aisha N. Hasan,
- John Glod,
- Rosandra N. Kaplan,
- Sandra P. D’Angelo,
- Dejka M. Araujo,
- Warren A. Chow,
- Mihaela Druta,
- George D. Demetri,
- Brian A. Van Tine,
- Stephan A. Grupp,
- Gregg D. Fine,
- Ioanna Eleftheriadou
Affiliations
- Alexandra Gyurdieva
- GlaxoSmithKline
- Stefan Zajic
- GlaxoSmithKline
- Ya-Fang Chang
- GlaxoSmithKline
- E. Andres Houseman
- GlaxoSmithKline
- Shan Zhong
- GlaxoSmithKline
- Jaegil Kim
- GlaxoSmithKline
- Michael Nathenson
- GlaxoSmithKline
- Thomas Faitg
- GlaxoSmithKline
- Mary Woessner
- GlaxoSmithKline
- David C. Turner
- GlaxoSmithKline
- Aisha N. Hasan
- GlaxoSmithKline
- John Glod
- National Cancer Institute
- Rosandra N. Kaplan
- National Cancer Institute
- Sandra P. D’Angelo
- Memorial Sloan Kettering Cancer Center
- Dejka M. Araujo
- University of Texas/MD Anderson Cancer Center
- Warren A. Chow
- City of Hope Comprehensive Cancer Center
- Mihaela Druta
- H. Lee Moffitt Cancer Center
- George D. Demetri
- Dana-Farber Cancer Institute and Ludwig Center at Harvard
- Brian A. Van Tine
- Washington University in St. Louis School of Medicine
- Stephan A. Grupp
- Kelly Center for Cancer Immunotherapy, Division of Oncology, Children’s Hospital of Philadelphia and University of Pennsylvania
- Gregg D. Fine
- GlaxoSmithKline
- Ioanna Eleftheriadou
- GlaxoSmithKline
- DOI
- https://doi.org/10.1038/s41467-022-32491-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Biomarkers predictive of response to T cell therapy remain to be better defined. This study identifies potential predictive and pharmacodynamic markers of response to NY-ESO-1 T-cell therapy in a solid tumor that may inform lymphodepletion, cell dose, and strategies to enhance anticancer efficacy.
