Nature Communications (Jun 2019)

Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes

  • Mi-Sun Kang,
  • Eunjin Ryu,
  • Seung-Won Lee,
  • Jieun Park,
  • Na Young Ha,
  • Jae Sun Ra,
  • Yeong Jae Kim,
  • Jinwoo Kim,
  • Mohamed Abdel-Rahman,
  • Su Hyung Park,
  • Kyoo-young Lee,
  • Hajin Kim,
  • Sukhyun Kang,
  • Kyungjae Myung

DOI
https://doi.org/10.1038/s41467-019-10376-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). Here authors use biochemical and single molecule measurements to show that ATAD5-RLC has the most potent PCNA unloading activity and forms structurally distinct intermediates compared to RFC-PCNA.