New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies

• Dina H. Dawood,
• Manal M. Sayed,
• Sally T. K. Tohamy,
• Eman S. Nossier

Affiliations

Dina H. Dawood

Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt

Manal M. Sayed

Labeled Compounds Department, Hot Labs.center, Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt

Sally T. K. Tohamy

Department of Microbiology and Immunology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt

Eman S. Nossier

Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt