OncoTargets and Therapy (Sep 2020)
CircRNAs: A New Chapter in Oral Squamous Cell Carcinoma Biology
Abstract
Hua-yang Fan,1,* Jian Jiang,2,* Ya-jie Tang,3 Xin-hua Liang,1 Ya-ling Tang1 1State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Department of Head and Neck Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of China; 3State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin-hua Liang; Ya-ling Tang Email [email protected]; [email protected]: With the rapid development of bioinformatics and gene sequencing technologies, understanding of circular RNAs (circRNAs) has been extended, and numerous studies have identified the key regulator role of circRNAs in a variety of diseases, especially in cancer. Recently, accumulated studies of oral squamous cell carcinoma (OSCC) have discovered the great potential of circRNAs, which can serve as prognostic or diagnostic biomarkers and affect the development and therapy of OSCC. In this review, we detail the new progress of circRNA research for OSCC in order to provide new strategies for clinical diagnosis and treatment.Keywords: circular RNA, oral squamous cell carcinoma, miRNA sponge, biomarker
