Brain-derived neurotrophic factor and mental disorders

Chin-Chuen Lin; Tiao-Lai Huang

Biomedical Journal (Apr 2020)

Brain-derived neurotrophic factor and mental disorders

Chin-Chuen Lin,
Tiao-Lai Huang

Affiliations

Chin-Chuen Lin: Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan
Tiao-Lai Huang: Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Genomic and Proteomic Core Laboratory, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Corresponding author. Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, 123, Ta-Pei Rd, Niao-Sung, Kaohsiung, 833, Taiwan.

Journal volume & issue: Vol. 43, no. 2
pp. 134 – 142

Abstract

Read online

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged from protein quantilization, to RNA expression measurements, to DNA sequencing, and lately but not lastly, epigenetic studies. In this review, we will briefly address findings on BDNF protein levels, mRNA expression, Val66Met polymorphism, and epigenetic modifications, in schizophrenia, major depressive disorder (MDD), and bipolar disorder.

Published in Biomedical Journal

ISSN: 2319-4170 (Print); 2320-2890 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.sciencedirect.com/journal/biomedical-journal

About the journal

Abstract

Keywords