Nature Communications (Apr 2016)

A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor

  • Camille Sayou,
  • Max H. Nanao,
  • Marc Jamin,
  • David Posé,
  • Emmanuel Thévenon,
  • Laura Grégoire,
  • Gabrielle Tichtinsky,
  • Grégoire Denay,
  • Felix Ott,
  • Marta Peirats Llobet,
  • Markus Schmid,
  • Renaud Dumas,
  • François Parcy

DOI
https://doi.org/10.1038/ncomms11222
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

The LEAFY transcription factor is a master regulator of flower development in plants. Here the authors describe the structure of a LEAFY oligomerization domain and show that mutations that disrupt oligomerization alter its capacity to bind low affinity and poorly accessible target sites.