Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk

Ulla Uusitalo; Carin Andren Aronsson; Xiang Liu; Kalle Kurppa; Jimin Yang; Edwin Liu; Jennifer Skidmore; Christiane Winkler; Marian J. Rewers; William A. Hagopian; Jin-Xiong She; Jorma Toppari; Anette-G. Ziegler; Beena Akolkar; Jill M. Norris; Suvi M. Virtanen; Jeffrey P. Krischer; Daniel Agardh; on behalf of the TEDDY Study Group

doi:10.3390/nu11081790

Nutrients (Aug 2019)

Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk

Ulla Uusitalo,
Carin Andren Aronsson,
Xiang Liu,
Kalle Kurppa,
Jimin Yang,
Edwin Liu,
Jennifer Skidmore,
Christiane Winkler,
Marian J. Rewers,
William A. Hagopian,
Jin-Xiong She,
Jorma Toppari,
Anette-G. Ziegler,
Beena Akolkar,
Jill M. Norris,
Suvi M. Virtanen,
Jeffrey P. Krischer,
Daniel Agardh,
on behalf of the TEDDY Study Group

Affiliations

Ulla Uusitalo: Health Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
Carin Andren Aronsson: The Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, 214 28 Malmö, Sweden
Xiang Liu: Health Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
Kalle Kurppa: Tampere Center for Child Health Research, University of Tampere, 33014 Tampere, Finland
Jimin Yang: Health Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
Edwin Liu: Digestive Health Institute, Children’s Hospital Colorado, University of Colorado Denver, Aurora, CO 80045, USA
Jennifer Skidmore: Pacific Northwest Research Institute, Seattle, WA 98122, USA
Christiane Winkler: Institute of Diabetes Research, Helmholtz Zentrum München, 85764 Munich-Neuherberg, Germany
Marian J. Rewers: Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO 80045, USA
William A. Hagopian: Pacific Northwest Research Institute, Seattle, WA 98122, USA
Jin-Xiong She: Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
Jorma Toppari: Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, 20014 Turku, Finland
Anette-G. Ziegler: Institute of Diabetes Research, Helmholtz Zentrum München, 85764 Munich-Neuherberg, Germany
Beena Akolkar: NIDDK, National Institute of Health, Bethesda, MD 20892, USA
Jill M. Norris: Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO 80045, USA
Suvi M. Virtanen: Tampere Center for Child Health Research, University of Tampere, 33014 Tampere, Finland
Jeffrey P. Krischer: Health Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
Daniel Agardh: The Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, 214 28 Malmö, Sweden
on behalf of the TEDDY Study Group: Membership of the TEDDY Study Group is provided in the Acknowledgments.

DOI: https://doi.org/10.3390/nu11081790
Journal volume & issue: Vol. 11, no. 8
p. 1790

Abstract

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Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.

Published in Nutrients

ISSN: 2072-6643 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.mdpi.com/journal/nutrients

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