Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP

Peter J Morin; Miguel Medina; Mikhail Semenov; Anthony M.C Brown; Kenneth S Kosik

Neurobiology of Disease (Jun 2004)

Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP

Peter J Morin,
Miguel Medina,
Mikhail Semenov,
Anthony M.C Brown,
Kenneth S Kosik

Affiliations

Peter J Morin: Center for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Research Laboratory at The Rockefeller University, New York, NY 10021, USA
Miguel Medina: Center for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Research Laboratory at The Rockefeller University, New York, NY 10021, USA
Mikhail Semenov: Center for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Research Laboratory at The Rockefeller University, New York, NY 10021, USA
Anthony M.C Brown: Center for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Research Laboratory at The Rockefeller University, New York, NY 10021, USA
Kenneth S Kosik: Center for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Research Laboratory at The Rockefeller University, New York, NY 10021, USA

Journal volume & issue: Vol. 16, no. 1
pp. 59 – 67

Abstract

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The metabolism of amyloid precursor protein (APP) is central to Alzheimer's disease pathogenesis. Recent data have linked APP and presenilin to the Wnt/wingless signaling pathway. To assess affects of Wnt stimulation on APP isoform expression, we infected PC12 cells and C57MG cells with a retrovirus containing murine Wnt-1. In PC12 cells, Wnt-1 expression is associated with induction of exon 15 deletion from APP mRNA and expression of L-APP. Our data suggest that APP isoform expression is regulated, in part, by the Wnt/wingless signaling pathway.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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