Temperature-dependent solubilization and thermodynamic characteristics of ribociclib in varied {PEG 400 + water} combinations

Abstract

Abstract The solubility and thermodynamic characteristics of ribociclib (RCB), a new anticancer medication, have been assessed in a range of {polyethylene glycol 400 (PEG 400) + water} combinations at 293.2–313.2 K and atmospheric pressure. RCB solubility was determined utilizing the saturation shake flask approach, and “van’t Hoff, Apelblat, Buchowski-Ksiazczak λh, Yalkowsky-Roseman, Jouyban-Acree, and Jouyban-Acree-van’t Hoff models” were utilized to validate the measured experimental data. The uncertainties for the computational predictions were less than 3.0% throughout the validation, indicating an outstanding relationship with the experimental RCB solubility data. PEG 400 mass fraction and temperature both improved the solubility of RCB in mole fraction in the compositions of {PEG 400 + water}. It was discovered that the RCB solubility in mole fraction was greatest in pure PEG 400 (1.04 × 10− 1) at 313.2 K and lowest in neat water (1.07 × 10− 6 at 293.2 K). All of the {PEG 400 + water} mixes under study showed “endothermic and entropy-driven” RCB dissolution, as indicated by the positive values of the estimated thermodynamic parameters. Compared to RCB-water, RCB-PEG 400 exhibited the strongest molecular interactions. PEG 400 offers a great potential for RCB solubilization in water, according to the evaluation’s findings.

Keywords

• Computational validation
• Dissolution
• {PEG 400 + water} mixtures
• Ribociclib
• Solubility
• Thermodynamics