Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection

Yusi Peng; Chenglong Lin; Li Long; Tanemura Masaki; Mao Tang; Lili Yang; Jianjun Liu; Zhengren Huang; Zhiyuan Li; Xiaoying Luo; John R. Lombardi; Yong Yang

doi:10.1007/s40820-020-00565-4

Nano-Micro Letters (Jan 2021)

Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection

Yusi Peng,
Chenglong Lin,
Li Long,
Tanemura Masaki,
Mao Tang,
Lili Yang,
Jianjun Liu,
Zhengren Huang,
Zhiyuan Li,
Xiaoying Luo,
John R. Lombardi,
Yong Yang

Affiliations

Yusi Peng: State Key Laboratory of High-Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences
Chenglong Lin: State Key Laboratory of High-Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences
Li Long: School of Physics and Optoelectronics, South China University of Technology
Tanemura Masaki: Department of Frontier Materials, Nagoya Institute of Technology
Mao Tang: State Key Laboratory of High-Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences
Lili Yang: State Key Laboratory of High-Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences
Jianjun Liu: State Key Laboratory of High-Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences
Zhengren Huang: State Key Laboratory of High-Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences
Zhiyuan Li: School of Physics and Optoelectronics, South China University of Technology
Xiaoying Luo: State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine
John R. Lombardi: City College, CUNY
Yong Yang: State Key Laboratory of High-Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences

DOI: https://doi.org/10.1007/s40820-020-00565-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Abstract The outbreak of coronavirus disease 2019 has seriously threatened human health. Rapidly and sensitively detecting SARS-CoV-2 viruses can help control the spread of viruses. However, it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor sensitivity. Therefore, it is worthwhile to search novel semiconductor-based substrates with excellent SERS sensitivity. Herein we report, for the first time, Nb2C and Ta2C MXenes exhibit a remarkable SERS enhancement, which is synergistically enabled by the charge transfer resonance enhancement and electromagnetic enhancement. Their SERS sensitivity is optimized to 3.0 × 106 and 1.4 × 106 under the optimal resonance excitation wavelength of 532 nm. Additionally, remarkable SERS sensitivity endows Ta2C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein. Moreover, its detection limit is as low as 5 × 10−9 M, which is beneficial to achieve real-time monitoring and early warning of novel coronavirus. This research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology.

Published in Nano-Micro Letters

ISSN: 2311-6706 (Print); 2150-5551 (Online)
Publisher: SpringerOpen
Country of publisher: Germany
LCC subjects: Technology
Website: http://www.springer.com/40820

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