Super enhancers: Pathogenic roles and potential therapeutic targets for acute myeloid leukemia (AML)

Ziyang Cao; Yi Shu; Jinxia Wang; Chunxia Wang; Tienan Feng; Li Yang; Jingbo Shao; Lin Zou

Genes and Diseases (Nov 2022)

Super enhancers: Pathogenic roles and potential therapeutic targets for acute myeloid leukemia (AML)

Ziyang Cao,
Yi Shu,
Jinxia Wang,
Chunxia Wang,
Tienan Feng,
Li Yang,
Jingbo Shao,
Lin Zou

Affiliations

Ziyang Cao: Clinical Research Unit, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, PR China; Institute of Pediatric Infection, Immunity, Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200062, PR China
Yi Shu: Center for Clinical Molecular Laboratory Medicine of Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China
Jinxia Wang: Clinical Research Unit, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, PR China; Institute of Pediatric Infection, Immunity, Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200062, PR China
Chunxia Wang: Clinical Research Unit, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, PR China; Institute of Pediatric Infection, Immunity, Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200062, PR China
Tienan Feng: Clinical Research Unit, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, PR China; Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China
Li Yang: Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China
Jingbo Shao: Department of Hematology/Oncology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, PR China; Corresponding author.
Lin Zou: Clinical Research Unit, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, PR China; Institute of Pediatric Infection, Immunity, Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200062, PR China; Center for Clinical Molecular Laboratory Medicine of Children's Hospital of Chongqing Medical University, Chongqing 400014, PR China

Journal volume & issue: Vol. 9, no. 6
pp. 1466 – 1477

Abstract

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Acute myeloid leukemia (AML) is a malignant hematological tumor with disordered oncogenes/tumor suppressor genes and limited treatments. The potent anti-cancer effects of bromodomain and extra-terminal domain (BET) inhibitors, targeting the key component of super enhancers, in early clinical trials on AML patients, implies the critical role of super enhancers in AML. Here, we review the concept and characteristic of super enhancer, and then summarize the current researches about super enhancers in AML pathogenesis, diagnosis and classification, followed by illustrate the potential super enhancer-related targets and drugs, and propose the future directions of super enhancers in AML. This information provides integrated insight into the roles of super enhancers in this disease.

Published in Genes and Diseases

ISSN: 2352-3042 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Medicine (General); Science: Biology (General): Genetics
Website: https://www.keaipublishing.com/en/journals/genes-and-diseases/

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Abstract

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