The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization

Feng Zhang; Claudia Prahst; Thomas Mathivet; Laurence Pibouin-Fragner; Jiasheng Zhang; Gael Genet; Raymond Tong; Alexandre Dubrac; Anne Eichmann

doi:10.1038/ncomms13517

Nature Communications (Nov 2016)

The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization

Feng Zhang,
Claudia Prahst,
Thomas Mathivet,
Laurence Pibouin-Fragner,
Jiasheng Zhang,
Gael Genet,
Raymond Tong,
Alexandre Dubrac,
Anne Eichmann

Affiliations

Feng Zhang: Department of Internal Medecine Cardiology, Cardiovascular Research Center, Yale University School of Medicine
Claudia Prahst: Department of Internal Medecine Cardiology, Cardiovascular Research Center, Yale University School of Medicine
Thomas Mathivet: INSERM U970, Paris Center for Cardiovascular Research (PARCC)
Laurence Pibouin-Fragner: INSERM U970, Paris Center for Cardiovascular Research (PARCC)
Jiasheng Zhang: Department of Internal Medecine Cardiology, Cardiovascular Research Center, Yale University School of Medicine
Gael Genet: Department of Internal Medecine Cardiology, Cardiovascular Research Center, Yale University School of Medicine
Raymond Tong: Molecular Oncology Division, Genentech Inc.
Alexandre Dubrac: Department of Internal Medecine Cardiology, Cardiovascular Research Center, Yale University School of Medicine
Anne Eichmann: Department of Internal Medecine Cardiology, Cardiovascular Research Center, Yale University School of Medicine

DOI: https://doi.org/10.1038/ncomms13517
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Robo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosphorylation of its receptor Vegfr2 on Y949.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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