Computational Portable Microscopes for Point-of-Care-Test and Tele-Diagnosis
Yinxu Bian,
Tao Xing,
Kerong Jiao,
Qingqing Kong,
Jiaxiong Wang,
Xiaofei Yang,
Shenmin Yang,
Yannan Jiang,
Renbing Shen,
Hua Shen,
Cuifang Kuang
Affiliations
Yinxu Bian
School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
Tao Xing
School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
Kerong Jiao
School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
Qingqing Kong
School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
Jiaxiong Wang
The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215002, China
Xiaofei Yang
School of Optoelectronic Science and Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215006, China
Shenmin Yang
The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215002, China
Yannan Jiang
The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215002, China
Renbing Shen
The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215002, China
Hua Shen
School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
Cuifang Kuang
College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China
In bio-medical mobile workstations, e.g., the prevention of epidemic viruses/bacteria, outdoor field medical treatment and bio-chemical pollution monitoring, the conventional bench-top microscopic imaging equipment is limited. The comprehensive multi-mode (bright/dark field imaging, fluorescence excitation imaging, polarized light imaging, and differential interference microscopy imaging, etc.) biomedical microscopy imaging systems are generally large in size and expensive. They also require professional operation, which means high labor-cost, money-cost and time-cost. These characteristics prevent them from being applied in bio-medical mobile workstations. The bio-medical mobile workstations need microscopy systems which are inexpensive and able to handle fast, timely and large-scale deployment. The development of lightweight, low-cost and portable microscopic imaging devices can meet these demands. Presently, for the increasing needs of point-of-care-test and tele-diagnosis, high-performance computational portable microscopes are widely developed. Bluetooth modules, WLAN modules and 3G/4G/5G modules generally feature very small sizes and low prices. And industrial imaging lens, microscopy objective lens, and CMOS/CCD photoelectric image sensors are also available in small sizes and at low prices. Here we review and discuss these typical computational, portable and low-cost microscopes by refined specifications and schematics, from the aspect of optics, electronic, algorithms principle and typical bio-medical applications.
