Cell & Bioscience (Jul 2021)
Effects of low lead exposure on sperm quality and sperm DNA methylation in adult men
- Tiancheng Zhang,
- Yan Fei Ru,
- Bin Wu,
- Haiyan Dong,
- Liang Chen,
- Jufen Zheng,
- Jianhui Li,
- Xin Wang,
- Zhikai Wang,
- Xuemei Wang,
- Xiaorong Shen,
- Jun Wu,
- Jun Qian,
- Maohua Miao,
- Yihua Gu,
- Huijuan Shi
Affiliations
- Tiancheng Zhang
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Yan Fei Ru
- Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University
- Bin Wu
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Haiyan Dong
- Shanghai Kelin Institute of clinical bioinformatics
- Liang Chen
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Jufen Zheng
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Jianhui Li
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Xin Wang
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Zhikai Wang
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Xuemei Wang
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Xiaorong Shen
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Jun Wu
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Jun Qian
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Maohua Miao
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Yihua Gu
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- Huijuan Shi
- NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University
- DOI
- https://doi.org/10.1186/s13578-021-00665-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Abstract Instruction Lead (Pb) exposure is a risk factor for male infertility, but the epigenetic changes in sperm DNAattributable to lead exposure is poorly defined. Methods In this study, we investigated whether low Pb exposure ( 5 µg/dL or when predicting NP, no significant Pb–Ca interaction was observed. Discussion Overall, our results indicate that aberrant DNA methylation of the Ca homeostasis pathway, induced by low Pb exposure, is the potential cause for reduced sperm velocity.
Keywords
- Low lead
- Sperm motility
- DNA methylation
- Calcium and lead interaction
- Calcium homeostasis regulation pathway
